Pathogenicity and antigenicity of a new influenza a (H5N1) virus isolated from duck meat
Identifieur interne : 001719 ( Main/Exploration ); précédent : 001718; suivant : 001720Pathogenicity and antigenicity of a new influenza a (H5N1) virus isolated from duck meat
Auteurs : X. Lu [Géorgie (pays)] ; D. Cho [Géorgie (pays)] ; H. Hall [Géorgie (pays)] ; T. Rowe [Géorgie (pays)] ; H. Sung [Corée du Sud] ; W. Kim [Corée du Sud] ; C. Kang [Corée du Sud] ; I. Mo [Corée du Sud] ; N. Cox [Géorgie (pays)] ; A. Klimov [Géorgie (pays)] ; J. Katz [Géorgie (pays), États-Unis]Source :
- Journal of Medical Virology [ 0146-6615 ] ; 2003-04.
English descriptors
- Teeft :
- Antibody response, Antibody titers, Antigenic, Antigenic analysis, Antigenic relationship, Anyang, Anyang virus, Assay, Avian, Avian species, Avian viruses, Cell counts, Death time, Disease control, Display leukopenia, Duck meat, Fatal disease, Fatal outcome, Genetic reassortment, Guan, Hemagglutinin gene, High doses, Hong kong, Human cases, Human disease, Human exposure, Human infection, Infection, Infectious dose, Internal genes, Intestinal tract, Katz, Krauss, Lesser extent, Lethal challenge, Leukopenia, Lymphocyte, Lymphoid, Lymphoid organs, Lymphopenia, Mammalian species, Mouse, Mouse model, Nasal washes, National center, Normal mice, Novel source, Osterhaus adme, Other organs, Outbreak, Pathogenicity, Peripheral blood lymphocyte counts, Primary infection, Public health, Replication, Respiratory tract, Respiratory tract tissues, Rowe, Same dose, Secondary lymphoid organs, Severe leukopenia, Severe reduction, Shortridge, Southeastern china, Southern china, Titer, Tumpey, Virol, Virol guan, Virology, Virus, Virus detection, Virus infection, Virus titers, Virusinfected mice, Weight loss, Zitzow.
Abstract
Avian influenza A viruses are the ancestral origin of all human influenza viruses. The outbreak of highly pathogenic (HP) avian H5N1 in Hong Kong in 1997 highlighted the potential of these viruses to infect and cause severe disease in humans. Since 1999, HP H5N1 viruses were isolated several times from domestic poultry in Asia. In 2001, a HP H5N1 virus, A/Duck/Anyang/AVL‐1/2001 (Dk/Anyang), was isolated from imported frozen duck meat in Korea. Because of this novel source of HP H5N1 virus isolation, concerns were raised about the potential for human exposure and infection; we therefore compared the Dk/Anyang virus with HP H5N1 viruses isolated from humans in 1997 in terms of antigenicity and pathogenicity for mammals. At high doses, Dk/Anyang virus caused up to 50% mortality in BALB/c mice, was isolated from the brains and lymphoid organs of mice, and caused lymphopenia. Overall Dk/Anyang virus was substantially less pathogenic for mice than the H5N1 virus isolated from a fatal human case in 1997. Likewise, Dk/Anyang virus was apathogenic for ferrets. Dk/Anyang virus was antigenically distinguishable by hemagglutination‐inhibition (HI) assay from human H5N1 viruses isolated in 1997 and avian H5N1 viruses isolated in 2001 in Hong Kong. Nevertheless, prior infection with Dk/Anyang virus protected mice from death after secondary infection with HP human H5N1 viruses. These results indicate that compared with HP human H5N1 viruses, Dk/Anyang virus is substantially less pathogenic for mammalian species. Nevertheless, the novel source of isolation of this avian H5N1 virus must be considered when evaluating the potential risk to public health. J. Med. Virol. 69:553–559, 2003. © 2003 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/jmv.10344
Affiliations:
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Sung</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Division, National Veterinary Research and Quarantine Service, Anyang</wicri:regionArea><wicri:noRegion>Anyang</wicri:noRegion></affiliation></author><author><name sortKey="Kim, W" sort="Kim, W" uniqKey="Kim W" first="W." last="Kim">W. Kim</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Center for Influenza, Laboratory of Respiratory Viruses, National Institute of Health, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Kang, C" sort="Kang, C" uniqKey="Kang C" first="C." last="Kang">C. Kang</name><affiliation wicri:level="3"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>National Center for Influenza, Laboratory of Respiratory Viruses, National Institute of Health, Seoul</wicri:regionArea><placeName><settlement type="city">Séoul</settlement><region type="capital">Région capitale de Séoul</region></placeName></affiliation></author><author><name sortKey="Mo, I" sort="Mo, I" uniqKey="Mo I" first="I." last="Mo">I. Mo</name><affiliation wicri:level="1"><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Avian Disease Division, National Veterinary Research and Quarantine Service, Anyang</wicri:regionArea><wicri:noRegion>Anyang</wicri:noRegion></affiliation></author><author><name sortKey="Cox, N" sort="Cox, N" uniqKey="Cox N" first="N." last="Cox">N. 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Katz</name><affiliation wicri:level="1"><country xml:lang="fr">Géorgie (pays)</country><wicri:regionArea>Influenza Branch, Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Géorgie (États-Unis)</region></placeName><wicri:cityArea>Correspondence address: Influenza Branch, Mailstop G‐16, Centers for Disease Control and Prevention, 1600 Clifton Road, NE, Atlanta</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Medical Virology</title><title level="j" type="alt">JOURNAL OF MEDICAL VIROLOGY</title><idno type="ISSN">0146-6615</idno><idno type="eISSN">1096-9071</idno><imprint><biblScope unit="vol">69</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="553">553</biblScope><biblScope unit="page" to="559">559</biblScope><biblScope unit="page-count">7</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-04">2003-04</date></imprint><idno type="ISSN">0146-6615</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0146-6615</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Antibody response</term><term>Antibody titers</term><term>Antigenic</term><term>Antigenic analysis</term><term>Antigenic relationship</term><term>Anyang</term><term>Anyang virus</term><term>Assay</term><term>Avian</term><term>Avian species</term><term>Avian viruses</term><term>Cell counts</term><term>Death time</term><term>Disease control</term><term>Display leukopenia</term><term>Duck meat</term><term>Fatal disease</term><term>Fatal outcome</term><term>Genetic reassortment</term><term>Guan</term><term>Hemagglutinin gene</term><term>High doses</term><term>Hong kong</term><term>Human cases</term><term>Human disease</term><term>Human exposure</term><term>Human infection</term><term>Infection</term><term>Infectious dose</term><term>Internal genes</term><term>Intestinal tract</term><term>Katz</term><term>Krauss</term><term>Lesser extent</term><term>Lethal challenge</term><term>Leukopenia</term><term>Lymphocyte</term><term>Lymphoid</term><term>Lymphoid organs</term><term>Lymphopenia</term><term>Mammalian species</term><term>Mouse</term><term>Mouse model</term><term>Nasal washes</term><term>National center</term><term>Normal mice</term><term>Novel source</term><term>Osterhaus adme</term><term>Other organs</term><term>Outbreak</term><term>Pathogenicity</term><term>Peripheral blood lymphocyte counts</term><term>Primary infection</term><term>Public health</term><term>Replication</term><term>Respiratory tract</term><term>Respiratory tract tissues</term><term>Rowe</term><term>Same dose</term><term>Secondary lymphoid organs</term><term>Severe leukopenia</term><term>Severe reduction</term><term>Shortridge</term><term>Southeastern china</term><term>Southern china</term><term>Titer</term><term>Tumpey</term><term>Virol</term><term>Virol guan</term><term>Virology</term><term>Virus</term><term>Virus detection</term><term>Virus infection</term><term>Virus titers</term><term>Virusinfected mice</term><term>Weight loss</term><term>Zitzow</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Avian influenza A viruses are the ancestral origin of all human influenza viruses. The outbreak of highly pathogenic (HP) avian H5N1 in Hong Kong in 1997 highlighted the potential of these viruses to infect and cause severe disease in humans. Since 1999, HP H5N1 viruses were isolated several times from domestic poultry in Asia. In 2001, a HP H5N1 virus, A/Duck/Anyang/AVL‐1/2001 (Dk/Anyang), was isolated from imported frozen duck meat in Korea. Because of this novel source of HP H5N1 virus isolation, concerns were raised about the potential for human exposure and infection; we therefore compared the Dk/Anyang virus with HP H5N1 viruses isolated from humans in 1997 in terms of antigenicity and pathogenicity for mammals. At high doses, Dk/Anyang virus caused up to 50% mortality in BALB/c mice, was isolated from the brains and lymphoid organs of mice, and caused lymphopenia. Overall Dk/Anyang virus was substantially less pathogenic for mice than the H5N1 virus isolated from a fatal human case in 1997. Likewise, Dk/Anyang virus was apathogenic for ferrets. Dk/Anyang virus was antigenically distinguishable by hemagglutination‐inhibition (HI) assay from human H5N1 viruses isolated in 1997 and avian H5N1 viruses isolated in 2001 in Hong Kong. Nevertheless, prior infection with Dk/Anyang virus protected mice from death after secondary infection with HP human H5N1 viruses. These results indicate that compared with HP human H5N1 viruses, Dk/Anyang virus is substantially less pathogenic for mammalian species. Nevertheless, the novel source of isolation of this avian H5N1 virus must be considered when evaluating the potential risk to public health. J. Med. Virol. 69:553–559, 2003. © 2003 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li><li>Géorgie (pays)</li><li>États-Unis</li></country><region><li>Géorgie (États-Unis)</li><li>Région capitale de Séoul</li></region><settlement><li>Séoul</li></settlement></list><tree><country name="Géorgie (pays)"><noRegion><name sortKey="Lu, X" sort="Lu, X" uniqKey="Lu X" first="X." last="Lu">X. Lu</name></noRegion><name sortKey="Cho, D" sort="Cho, D" uniqKey="Cho D" first="D." last="Cho">D. Cho</name><name sortKey="Cox, N" sort="Cox, N" uniqKey="Cox N" first="N." last="Cox">N. Cox</name><name sortKey="Hall, H" sort="Hall, H" uniqKey="Hall H" first="H." last="Hall">H. Hall</name><name sortKey="Katz, J" sort="Katz, J" uniqKey="Katz J" first="J." last="Katz">J. Katz</name><name sortKey="Klimov, A" sort="Klimov, A" uniqKey="Klimov A" first="A." last="Klimov">A. Klimov</name><name sortKey="Rowe, T" sort="Rowe, T" uniqKey="Rowe T" first="T." last="Rowe">T. Rowe</name></country><country name="Corée du Sud"><noRegion><name sortKey="Sung, H" sort="Sung, H" uniqKey="Sung H" first="H." last="Sung">H. Sung</name></noRegion><name sortKey="Kang, C" sort="Kang, C" uniqKey="Kang C" first="C." last="Kang">C. Kang</name><name sortKey="Kim, W" sort="Kim, W" uniqKey="Kim W" first="W." last="Kim">W. Kim</name><name sortKey="Mo, I" sort="Mo, I" uniqKey="Mo I" first="I." last="Mo">I. Mo</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Katz, J" sort="Katz, J" uniqKey="Katz J" first="J." last="Katz">J. Katz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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